Journal: Molecular Pain
Article Title: Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity
doi: 10.1177/17448069241285357
Figure Lengend Snippet: (a) The plantar incision induced a reduction in mechanical threshold against von Frey stimulation. Intrathecal IL-1RA administration significantly inhibited the reduction of the mechanical threshold for 6 h after the treatment. (b) The plantar incision induced a reduction in latency time against thermal stimulation. Intrathecal IL-1RA administration significantly inhibited reduction in the thermal pain latency for 6 h after the treatment. Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01, ### p < .001), and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01, *** p < .001). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group). i.t.: intrathecal administration. Intrathecal administration of IL-1β induced reduction of the mechanical threshold against von Frey stimulation (c) and reduction of latency time against thermal stimulation (d). Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01) and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group).
Article Snippet: Mice were randomly assigned to saline and IL-1 RA (500 ng/5 μL, diluted in saline, Recombinant Human IL-1ra/IL-1F3, #280-RA/CF, R&D Systems, Inc. Minneapolis, MN 55413) groups ( n = 6 per group).
Techniques: Comparison
